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doi: 10.1111/bph.15930 245 CarabottiMSciroccoAMaselliMASeveriC

In addition, CRISPR-engineered reporter systems, such as tyrosine hydroxylase (TH)-linked fluorescent tags and lineage tracers, enable real-time visualization, purification and longitudinal tracking of DA neurons while preserving endogenous regulation, which is crucial for high-content phenotyping and enables the precise assessment of drug effects and screening 43,44,45,46