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By contrast, copper chelators such as TM protect against ferroptosis-related tissue damage (e.g., in acute pancreatitis) by promoting GPX4 ubiquitination and aggregation through direct binding to cysteine residues (C107/C148) (226)

6 Pyruvate kinase (PK) catalyzes the conversion of phosphenolpyruvate to pyruvate and is the rate-limiting enzyme in erythrocyte energy production, which is an exclusively anaerobic process

10.1016/j.cmet.2021.12.010 20 Pedro-BotetJ.ClimentE.BenaigesD

Pharm Res (2019) 2(1):513