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Description

The innate immune system provides the first line of defense against pathogens and utilizes pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) as well as endogenous ligands released in response to cellular damage (DAMPs)

The female MRL/lpr mice have lower Lactobacillaceae and higher Lachnospiraceae than the control group

Additional information Peer review information Nature Reviews Disease Primers thanks Hartmut Gbel, Andrew Hershey, Michel Lanteri-Minet, Cristina Tassorelli and the other, anonymous, reviewer(s) for their contribution to the peer review of this work