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2013;4:112 Nature Publishing Group

Reactive oxygen species (ROS) and their derived superoxide radicals can trigger cytotoxic effects through multiple mechanisms: first, excessive generation of ROS induces lipid peroxidation and leads to depletion of intracellular antioxidant enzyme levels, exacerbating the disruption of redox homeostasis

Cellular uptake was evaluated in SH-SY5Y neuroblastoma and hBMECs using confocal laser scanning microscopy and flow cytometry revealing 5.4X higher uptake of lactoferrin-conjugated nanoparticles as compared to non-conjugated PLGA NPs following 5 h of exposure

Diet as a modifiable factor in tumorigenesis: focus on microbiome-derived bile acid metabolites and short-chain fatty acids

The mechanism likely involves chromatin remodeling in cells of the intestinal epithelium and pancreas