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Activated NF-B not only promotes the formation of OCs but also promotes the production of proinflammatory factors, forming a vicious cycle of positive feedback regulation, which further increases the progression of RA

IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis

Further research is necessary to determine whether excess copper inhibits enzymes critical for these well-known cell death pathways

Since phytoestrogens and xenoestrogens can be considered as omnipresent molecules in our daily diet, they are becoming an increasingly attractive focus of research on human health and disease (Table 1)