Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]
When skin is under stress (weather, over-exfoliation, lack of sleep, life), it can start looking thinner, duller, and less firm
Pickart et al., 2018 GHK-Cu Regenerative Clinical Review Main Conclusion: A comprehensive review of GHK-Cu clinical data confirms its ability to reverse follicle miniaturization and match the efficacy of clinical-standard treatments
For researchers studying comprehensive skin regeneration, GHK-Cus multi-pathway approach addresses collagen production, inflammation, oxidative stress, and cellular repair simultaneously capabilities Matrixyl cannot match
Pickart, Control of fibrinogen biosynthesis: The role of free fatty acid, Journal of Atherosclerosis Research, Volume 8, Issue 1, 1968, Pages 155-166, ISSN 0368-1319, Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B