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This condition is induced by accumulation of cell remnants from various cell death pathways ( The Role of Iron and ROS in Ferroptosis and SLE Ferroptosis, a non-apoptotic form of cell death, is characterized by two major biochemical characteristics: iron accumulation and lipid peroxidation ( Interestingly, it has been documented that iron metabolism and lipid peroxidation play crucial roles in autoimmunity ( Importantly, the successful treatment of ferroptosis inhibitors in lupus-prone mice models provided direct evidence for the role of ferroptosis in lupus pathogenesis

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As a result, there is a continuing need for research to develop a cell-based assay for NQO1 as part of screening programs for modulation of NQO1 activity 3