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Supplementary Table S1 provides a condensed checklist designed for replication and peer-review clarity

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Mitochondrial dysfunction can drive senescence via reactive oxygen species (ROS) accumulation [68, 69], and Tat ( morphine) perturbs mitochondrial function, increasing ROS, protein oxidation, and cytokine release in microglia [60, 70]

MOTS-c and exercise-induced physical decline Reynolds JC et al

Leta V., Klingelhoefer L., Longardner K., et al., Gastrointestinal Barriers to Levodopa Transport and Absorption in Parkinson's Disease, European Journal of Neurology 30, no