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Their mechanisms of action are mainly to inhibit lipid peroxidation, promote the recovery of the liver cell membrane, eliminate oxygen free radicals, inhibit mitochondrial dysfunction, ameliorate cholestasis, and inhibit the secretion of inflammatory factors (Fig

89 ROS may also activate antiangiogenic pathways, such as p53-mediated production of thrombospondin-1

10.1074/jbc.M413544200 36 SatoK.YukitakeH.NaritaY.ShojiM.NaitoM.NakayamaK

Among all tested combinations, the ZIC-HILIC column provided the best performance in terms of retention and selectivity, as evidenced by distinct retention factors for both analytes (Fig