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In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

doi: 10.3390/antiox11010167 32 GutteridgeJMHalliwellB

Dopamine system involvement adds another regulatory dimension

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