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Similarly, apolipoprotein A-IV, which is synthesized and secreted exclusively by the small intestine (primarily by the jejunum, but also by the duodenum and ileum), acts as a satiety factor that is downregulated by leptin (188) and upregulated by insulin and PYY in both rodents and humans (189)

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Although they contain the same active ingredient, the primary differences between Ozempic and Wegovy are the dose of semaglutide in each pen and what each is approved to treat