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Primary outcomes were changes in the immune and metabolic profile before and after the intervention and at the 4-week follow-up

This steep gradient from inside the cell to outside the cell drives the export of GSH

doi: 10.3389/fmed.2025.1565275 Received 22 January 2025 Accepted 20 May 2025 Published 13 June 2025 Corrected 14 July 2025 Volume 12 - 2025 Edited by Jlio Belo Fernandes, Egas Moniz Center for Interdisciplinary Research (CiiEM), Portugal Reviewed by Ajith Sominanda, Qatar University, Qatar Ricardo Antunes, Egas Moniz Center for Interdisciplinary Research (CiiEM), Portugal Updates Copyright 2025 Anghelescu, Munteanu, Spinu, Ciobanu, Popescu, Cioca, Andone, Stoica, Mandu, Rebedea, Giuvara, Malaelea, Vladulescu-Trandafir, Morcov and Onose

Blood was collected prior to dosing and at predetermined collection times before and after the last dose to assess NAC, cysteine, GSH, catalase, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) concentrations and reduced-to-oxidized GSH ratio (GSH/GSSG)

IL-21 stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma