In particular, we previously showed that CD38 is the main NAD + -hydrolyzing enzyme in mammalian tissues, and its upregulation largely accounts for age-dependent decline in NAD + 11,17,18,19
The clinical utility of conventional copper chelators is limited by dose-dependent toxicities, primarily stemming from systemic copper deficiency and off-target chelation of essential metals, such as zinc and iron
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Genes with a Bonferroni-corrected P value of less than 0.05 were considered to be differentially expressed
Intensive Care Med 2017
