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Evolution of both Parkinsons disease and Alzheimers disease is in some way linked to brain insulin and related metabolic dysfunctions with putative links also with the diabetes type 2

these are crucial to progression to MASH ( The interplay between MASLD, insulin resistance, and metabolic syndrome MASLD is strongly associated with metabolic syndrome, which includes obesity, T2DM, dyslipidemia, and hypertension (Figure 2) ( Figure 2 Obesity is widely recognized as a key factor in promoting systemic inflammation, which is closely linked to the development of IR (Figure 2) ( IR is considered a central mechanism in the development and progression of MASLD to MASH and cirrhosis, impairing the liver's ability to manage fat (Figure 2) (56)

Harv Health Lett 2004 30(1):3 E

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