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Apoptosis describes a programmed mode of cell death that is characterized by a series of biochemical events that ultimately lead to cell fragmentation into compact membrane-enclosed structures, called apoptotic bodies that are taken up by neighboring cells and phagocytes, preventing inflammation, and tissue damage (Taylor et al., 2008)

261 When IT therapies are combined with ICIs, systemic immune-related adverse events (irAEs), such as hepatitis, pneumonitis, or thyroiditis, may occur, highlighting the need for adaptive dosing, step-up schedules, and close clinical monitoring

Expect at least 46 weeks of treatment for most cases

Timing considerations: BPC-157 typically divides into twice-daily dosing for stable tissue levels