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Furthermore, inhibition of phosphofructokinase-1 would lead to a buildup of fructose-6-phosphate, leading to a buildup of glucose-6-phosphate through phosphoglucose isomerase, which would be diverted to the pentose phosphate pathway, as it has been demonstrated 193,194

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However, Vitamin B12 supports normal energy metabolism, and people with low B12 levels may feel more supported after addressing a deficiency or insufficiency