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The increase in the males could be explained by a higher concentration gradient for the buprenorphine to leave the SC tissues, resulting in a higher-than-predicted C max and AUC 0-t [18]

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It is naturally produced in our bodies and is found in every cell, particularly in the liver, where it plays a vital role in detoxification, immune function, and cellular repair

T and B lymphocytes both originate from lymphoid precursors in the bone morrow, but whereas B cells complete their maturation in the bone marrow, before entering the circulation, T cells leave the bone marrow at an immature stage and migrate to the thymus where they mature [28]

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