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Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]

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154-158 At follow-up durations ranging from six weeks to 12 months, efficacy rates ranged from 61% to 70% with some studies also reporting significant improvements in voiding parameters and validated questionnaires