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This indicates that older adults might be more susceptible to AKI during periods of hypoperfusion, as they display a weakened vasodilatory capacity combined with an intact, or potentially augmented, vasoconstrictive response ( Furthermore, a study conducted by the TRIBE-AKI Consortium involving 1444 patients undergoing cardiac surgery showed that postoperative VEGF and placental growth factor (PGF) levels were inversely linked to AKI risk and mortality, whereas VEGR levels were positively associated with AKI and mortality (Mansour et al., 2019)