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Babaev V, Fazio S, Gleaves L, Carter K, Semenkovich C, Linton M

Furthermore, the precise timing and regulation of NLRP3 inflammasome activation in balancing immune defense versus tissue injury is still not fully understood

ACE2 deficiency has also been associated with increased NADPH oxidase 2 (Nox2) mediated oxidant formation, resulting in oxidative stress and thrombotic events in COVID-19 patients [129, 130]

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Conclusion: These results highlight that the combination of ALP and TB trajectories, regardless of duration from UDCA initiation, track with long-term outcomes and are useful criteria for identifying patients who could be considered for second-line therapy