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Conversely, salicin treatment facilitated Nrf2 nuclear translocation in RA-FLSs and stimulated downstream HO-1 expression, thereby reducing ROS levels

Hashimoto disease is the primary type with reduced production of thyroid hormone (TH) and increased the production of thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH)

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Proglucagon is subsequently processed by the prohormone convertases 1, 2 and 3 50 to produce, among other products, the 29-amino-acid-long GCG (in human, positions 5381, PSCK2) and the 30-amino-acid-long GLP-1 736 (positions 98127, PSCK1), which are the focus of this work