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Beyond DNA nuclease, other DDR components may mechanically catalyze immunological factors, which further trigger the development of inflammasomes or the release of pro-inflammatory cytokines

While the application of antioxidants has been suggested as a potential therapy to suppress the immune response in cases where an intensified inflammatory reaction occurs, the use of multiple antioxidant agents can be beneficial as they can act additively or synergistically on different pathways, thereby enhancing the antioxidant defense

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The chapter authors subsequently drafted the background and recommendation texts, which were reviewed, and put to an online vote by all members of the German Parkinson Guideline Group