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(1997) reported that PD patients who received long-term levodopa treatment had elevated plasma bilirubin levels, showing a protective effect, whereas in most studies, treatment of PD patients was not recorded, making it impossible to adjust for drug effects, thus leading to bias in cross-sectional comparisons (Songsomboon et al., 2020)

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Additionally, it is of utmost importance to utilize advanced technologies such as single-cell sequencing and multi-omics to deeply explore the molecular mechanisms of L