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The increases were modest and did not cause clinical concern, but users with pre-existing cardiac conditions should discuss this with healthcare providers

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We introduced these mutations, using CRISPR/Cas9, into a well-characterized control iPSC line (K7-4Lf), obtained earlier from a clinically healthy individual 33 (Supplementary Table S2) and recovered 66 clones for the D91A variant and 124 clones for the G128R variant of which 6 (9.1%) and 4 (3.2%) clones, respectively, were positive for the target mutations

But unfortunately, almost all very sick patients are deficient

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