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y attaching cationic molecules (like chitosan and albumin) or using a cationic polymer core, drugs are encapsulated inside, and ligands are coated on the surface

Michels J, Vitale I, Senovilla L, Enot DP, Garcia P, Lissa D et al

PML has traditionally been treated with all-trans retinoic acid (ATRA) paired with anthracycline-based chemotherapy (typically danorubicin) [2]

further evidence that this is a benign disorder

As such, interventions aimed to reduce SOD1 G93A expression and/or SOD1 G93A protein accumulation are most likely to achieve large rescuing effects in this model, whereas interventions that do not directly target the SOD1 G93A mechanisms are less likely to achieve success in retarding motor neuron disease of this model 23,24,25