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Moreover, studies linking the severity of bipolar symptoms to tardive dyskinesia, even in the absence of pharmacotherapy, lend further support to claims of dopamine dysfunction in this disease state (246)

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The main races affected are West Africa, the Mediterranean, the Middle East, and South-East Asia

Metformin treatment decreased the abundance of species of Bacteroides fragilis and its bile salt hydrolase activity in the intestines of individuals with T2D, increasing the levels of the bile acid glycoursodeoxycholic acid to inhibit intestinal FXR signaling (47)