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If this happens consistently, switch to a shorter needle, use a 45-degree angle instead of 90 degrees, or choose a site with more subcutaneous tissue like the abdomen

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Additionally, SNPs in seven genes, namely, thymidylate synthase ( TYMS ), methionine synthase ( MTR ), methionine synthase reductase ( MTRR ), methylenetetrahydrofolate reductase ( MTHFR ), dihydrofolate reductase ( DHFR ), cystathionine beta-synthase ( CBS ), and betaine-homocysteine methyltransferase ( BHMT ), are associated with the folate and methionine cycle [11, 12, 18,19,20,21]