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Mitochondrial dysfunction in Kupffer cells plays a central role: IR causes Kupffer cell mitochondria to release mtDNA and ROS, activating NLRP3 inflammasomes which then release IL-1 that amplifies neutrophil recruitment (67)

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Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification

Immune cell exploration and ceRNA networks shed light on the underlying disease mechanisms, while molecular docking proposed luteolin, isoflavone, and thalidomide as promising therapeutic contenders (70) (Table 3)

doi: 10.1038/nature16451 235 KroesenVMGroschelMIMartinsonNZumlaAMaeurerMvan der WerfTSet al