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Innovative technologies that enable targeting of undruggable targets include targeted protein degradation, such as proteolysis-targeting chimera (PROTAC) molecules that can degrade a target protein by controlling the ubiquitinproteasome system

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Recent work has also indicated that BSO can potentiate the toxicity of TMZ-induced bystander effect on glioblastoma cells 36 and a GSH transferase inhibitor was shown to potentiate the cytotoxic effect of TMZ in melanoma cells

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Persistent modification of the long half-life E3 ligase DCAF16, together with the relatively slow resynthesis rate of BRD9 in MV4-11 (8.6 h as determined by cycloheximide chase assay, Supplementary Fig