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Control Release 211 , 144162 (2015)

G1, G2 and G3 showed onefold, 1.3 fold and 1.1 fold increase in activity of APX as compared to control

4.3 Pharmacokinetic parameters in Sprague-Dawley rats after intravenous and intramuscular administration A total of 324 SD rats were randomly divided into five groups, including 66 rats in group one, 60 rats each in groups two to four, and 78 rats in group five, with each group comprising half male and half female subjects

Previous studies have shown that targeting GLUD1 inhibits the proliferation and migration of cancer cells, suggesting that GLUD1 is a druggable target for cancer therapy 23