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10.1016/j.jconrel.2003.09.010 122 PeiP.ZhangY.JiangY.ShenW.ChenH.YangS.et al (2022)

The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models

Upon activation, CX3CR1-mediated chemotaxis induces a shift to an amoeboid shape, accompanied by upregulation of TREM2-dependent phagocytic receptors and P2X7R activation, triggering dynamic secretion of pro-inflammatory cytokines (e.g., IL-1, TNF-) or anti-inflammatory factors (e.g., IL-10, TGF-)