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At the same time, we noticed, that SHBG does not affect the morphological architecture of EqASCEMS growth pattern which correlates with our previous findings in which we demonstrated that the exogenous SHBG treatment enhanced the proliferation, cell cycle progression, and survival of ASCs, while concurrently decreasing the expression of p53 and p21 , which are known as pro-apoptotic mediators [34]

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