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As described above, studies of murine models deficient in HSL have confirmed the importance of HSL for breakdown of DAG

ISSN 2072-6643

doi: 10.1186/s13014-019-1396-8 60 MarziSFarnetiAVidiriADi GiulianoFMarucciLSpasianoFet al

Notably, Dihexa did not improve performance in rats with normal, unimpaired cognition, suggesting the compounds effects are conditional on an existing deficit rather than representing generalized cognitive stimulation