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This mechanism is considered a major driver of PD pathogenesis and interacts with mitochondrial dysfunction, lysosomal pathway abnormalities, and neuroinflammation to facilitate disease progression (158)

doi:10.1016/j.jacc.2021.02.009 Stanescu AMA, Simionescu AA, Diaconu CC

10.1002/jnr.21950 J

The potential therapeutic approaches targeting gut health in ME/CFS Considering the common links between ME/CFS and dysbiosis, increased gut permeability, and chronic inflammation [12, 21,22,23,24,25,26,27,28,29,30,31, 40, 41], it is reasonable to hypothesize that strategies focused on restoring microbial equilibrium, enhancing mucosal barrier function, and reducing inflammation could have therapeutic potential