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After entering hepatocytes, approximately 90% of the APAP at therapeutic doses undergoes glucuronidation and sulfation before renal excretion, and a small fraction, approximately 5%10%, is oxidized by the cytochrome p450 (CYP450) family of enzymes (primarily CYP1A2, CYP2E1, and CYP3A4) to form toxic N-acetyl-p-benzoquinone-imine (NAPQI) ( Mathematical models have been developed to simulate APAP metabolism and the mechanism of liver injury, but these models often lack spatial resolution or integration with systemic pharmacokinetics, limiting their translational capability

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Rheumatoid arthritis, an autoimmune disorder, can cause inflammation in the wrist joints and lead to pain, swelling, and eventual joint damage