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Objective response rates (all partial responses) were 12.2% in the sorafenib group and 0.5% in the placebo group

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Through separate mechanisms, AMPK stimulates glucose uptake by phosphorylating TBC domain family member 1 (TBC1D1) and thioredoxin-interacting protein (TXNIP), which regulate the movement and surface expression of GLUT4 and GLUT1

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[DOI] [PubMed] [Google Scholar] 360.Sekhar KR, Meredith MJ, Kerr LD, Soltaninassab SR, Spitz DR, Xu ZQ, Freeman ML