fsp1 is a glutathione-independent ferroptosis suppressor.

fsp1 is a glutathione-independent ferroptosis suppressor. The dual role of in programmed cell death: resisting in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells | Molecular Medicine Sabotaging the breaks: FSEN1 expands

Name: fsp1 is a glutathione-independent ferroptosis suppressor. The dual role of in programmed cell death: resisting in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells | Molecular Medicine Sabotaging the breaks: FSEN1 expands
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Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors: Cell Chemical Biology Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance ScienceDirect Structural insights into FSP1 catalysis and ferroptosis inhibition Nature Communications FSP1 mediated ferroptosis in cancer: from mechanisms to therapeutic applications Apoptosis Springer Nature Link Proposed model for the catalytic and anti ferroptotic mechanism of Download Scientific Diagram

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Its triple-agonist profile also makes it a useful comparator compound in studies evaluating metabolic pathway interactions

& Ensinck, J

The most common ones among real-world patients seem to be headaches, nausea, dizziness, and injection site redness or irritation that should subside with use