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The lack of clinical improvement after 48 weeks for anemia and after 612 months for neurological signs could suggest that the symptoms are not due to B12 deficiency or that the dose of vitamin B12 or the route of administration needs to be adjusted to the severity of symptoms

Gut 2006;55:3427

For instance, studies have shown that consumption of broccoli sprouts, which are particularly rich in sulforaphane, can increase cellular glutathione levels

Thiamin supplements may also help for people who experience: malabsorption syndrome severe, prolonged vomiting gastric bypass surgery renal replacement therapy hyperthyroidism People who are pregnant, lactating, or use diuretics may also benefit from vitamin B1 supplements