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Given the established mechanisms of ammonia-induced cell death in CD8+ T cells, inducing ammonia-induced cell death in tumor cells through excessive ammonia accumulation presents a promising avenue for cancer immunotherapy research

doi:10.1016/j.meatsci.2013.11.022

They follow a predictable pattern that correlates directly with dose level

Even though HIF-1 and HIF-2 are structural similarity, sharing a 48% identical amino acid sequence, numerous studies employing various methodologies indicate that these two factors have distinct functions and gene targets [2, 3]

Barsyte-Lovejoy D, Lau SK, Boutros PC, Khosravi F, Jurisica I, Andrulis IL, Tsao MS, Penn LZ