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[DOI] [PMC free article] [PubMed] [Google Scholar] 243.Sorrentino, V

The FDA mandates that peptide manufacturers follow good manufacturing practices (GMPs) and conduct clinical trials to demonstrate the safety and efficacy of their products

The skin under the eyes is delicate and often the first area to show signs of aging, fatigue, and stress, which can cause dark circles and wrinkles to become more prominent, says DeMartino

meaning that animal studies have shown some adverse effect or there are no well-controlled studies in humans, but potential benefits may warrant use despite potential risks

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