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Although BI 836858 reduced MDSCs in preclinical studies, it failed to lower overall MDSC numbers or activate NK cells in myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) patients, leading to the termination of clinical development (88)

Metabolic Regulation: Restoration of SCFA production, particularly butyrate, activates G-protein-coupled receptors (GPR41/43), inhibits the NF-B signaling pathway, and reduces the release of pro-inflammatory cytokines such as IL-6 and TNF- (Siddiqui and Cresci, 2021

: IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G