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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

In 2016, researchers found that urolithin A was able to extend the lifespan of a worm by 45%, and another study found it increased the survival rate of mice with Duchenne muscular dystrophy (DMD).6 Of course, more research on humans is needed

Srivastava S, Kumar R, GUPTA GN, SINGH VP, SINHA A

Annexin A2 and its downstream IL-6 and HB-EGF as secretory biomarkers in the differential diagnosis of Her-2 negative breast cancer

J Int Med Res 48(7):300060520943824