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The ERa/ER receptors trigger the phosphorylation of eNOS via activation of the Src/the extracellular signal-regulated kinases 1 and 2 (ERK1/2)/phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, whereas the GPER-1 receptor does so through the Src/epidermal growth factor receptor (EGFR)/PI3K signaling pathway, leading to the rapid release of NO for the regulation of vascular tension

95% CI 0.792.43, p for trend 0.37), however, the 95% CI of the point estimate included the null-effect value

Our results are in agreement with previous studies performed in bovines, where oocytes subjected to heat stress before 12 h of maturation 49 , or even in the short term at the early stage of maturation, resulted in increased Annexin-V binding and oocytes that underwent early apoptosis compared with those in the control group 51

49%) (Zojaji 2009)

In the present experiments, OVX mice showed an increased expression of ALP in osteoblasts accompanied by increased number of well-round TRAP positive cells compared with that in SHAM group, indicating a relatively higher bone turnover rate 5,19