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( H ) Interstitial fibrosis in the LV evaluated using Masson trichrome staining in WT and hetKO mice treated with Veh or DOX

Abbasi B, Dong Y, Rui R

It has been proposed that RBC hemolysis products (heme, hemin and iron) induce the generation of reactive oxygen species (ROS) such as superoxide radicals and hydrogen peroxide 35 and that ROS are believed to affect platelet function and promote platelet activation both directly through the action of superoxide radicals, and indirectly through nitric oxide inhibition which contributes to platelet aggregation and thrombus formation 36

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10.1016/j.mce.2017.05.015 119