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Heuer M, Hussmann B, Lefering R, Taeger G, Kaiser GM, Paul A, Lendemans S

Persistent driving forces, such as smoking, aging, and other multifactorial risks, are responsible for this increasing incidence [3]

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Azelaic acid: Helps reduce inflammation & has a mildly suppressive role on pigment producing cells

In patients with hyperprolinemia, proline accumulation can cause a decrease in ATPase activity, which further leads to mitochondrial stress and elevated lactate levels, and can also decrease glutamate uptake [17]