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Oxidative damage model of 293T cell The determination of cell viability of oxidative damage was performed according to a previous report with modifications (Sun et al., Human embryonic 293T kidney cells were purchased from Boster Biological Technology Co., Ltd

Eriodictyol , another flavonoid, was found to upregulate Nrf2/HO-1 and reduce ROS levels in a renal injury model, providing protection against CP-induced AKI ( Eriodictyol has been shown to inhibit ferroptosis and improve cognitive deficits in APP/PS1 mice through activation of the Nrf2/HO-1 pathway (Li et al., 2022

He also received regular paracetamol analgesia

Mutagenesis In the published literature, acetaminophen has been reported to be clastogenic when administered at 1500 mg/kg/day to the rat model (3.6 times the MHDD, based on a body surface area comparison)