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This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]

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Overall, UA demonstrates a broad capacity to reverse multidrug resistance in various cancer types, thereby enhancing the efficacy of common chemotherapy and targeted drugs

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Oral bioavailability of 5-Amino-1MQ has not been characterised in any published pharmacokinetic study