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The Log Rank Mantel-Cox comparison among the three groups was statistically significant, with a p-value of 0.045

Sixteen participants were excluded from analyses due to statin use (muscle IR, 7.7%, n = 11

IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity

As TDP-43 SUMOylation is involved in supporting the normal cellular stress response and maintaining TDP-43 proteostasis, we hypothesized that disrupting this process leads to age-dependent physiological changes accelerated by impaired stress responses and TDP-43 accumulation

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days