glutathione reduces toxicity of alcohol Genes: Alcohol Metabolism Rate Ethanol Metabolism and Its Impact

Since selenium supplementation in the forms of sodium selenite and SeM was well documented to induce the expressions of seleno-GPxs through their metabolic assimilation into bioavailable selenium (hydrogen selenide), the initial studies focused on exploring selenium supplementation as a strategy to achieve protection against radiation-induced toxicity [38, 66]

After GSH donates its electron, it becomes oxidized and leads to the formation of glutathione disulfide (GSSG)

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In excess, these highly-reactive species cause oxidative stress which is responsible for significant cell damage

The scheme of strategy for identifying SG-associated proteins by mass spectrometry (MS)