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This validates the hypothesis that ferroptosis plays a critical pathological role after a hemorrhagic stroke

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Tabe Y, Harada M, Miyamae Y, Matsushita H, Kojima K, Fujimura T, Kazuno S, Ueno T, Miida T, Konopleva M, Andreeff M

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Stimulation of NMDARs (75) induces iron deposition in cells by activating the GTP (guanosine triphosphate) -binding protein Dexrasl, which contributes to activate the metal ion transporters, including the divalent metal transporter-1 (DMT1) (76) found that intravitreal injection of NMDA led to Fe 2+ accumulation in RGCs and triggered their apoptosis, resulting in a lower number of cells 7 days after injection